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In July 1968 an outbreak of influenza A2 was reported from Hong Kong, the largest outbreak in that area since 1957. Although strains of influenza virus from this outbreak crossreact to some extent with some previous A2 strains, they do show a marked antigenic change from previous strains. Similar viruses were subsequently isolated from an outbreak in Singapore.
These developments have led to a reappraisal of the influenza prospectus for the United States and the following recommendations on the use of influenza vaccine.
The continued change in antigenic characteristics of influenza viruses isolated over the years
Influenza Vaccines: Supplementary Recommendations on Use of Vaccine for A2/Aichi/2/68-Hong Kong Variant: From the Advisory Committee on Immunizing Practices, U. S. Public Health Service. Ann Intern Med. 1968;69:1013–1014. doi: https://doi.org/10.7326/0003-4819-69-5-1013
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Published: Ann Intern Med. 1968;69(5):1013-1014.
Infectious Disease, Prevention/Screening, Vaccines/Immunization.
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