HARVEY D. PREISLER, M.D.; HERBERT F. HASENCLEVER, PH.D.; ALEXANDER A. LEVITAN, M.D.; EDWARD S. HENDERSON, M.D.
Agglutinating and precipitating antibodies against Candida albicans were measured in serial antemortem serum samples obtained during the last 1 to 5 months of life of 33 patients dying of acute leukemia at the National Cancer Institute between 1965 and 1967. Of the 23 patients who had visceral candidiasis on autopsy, 14 exhibited a significant rise in agglutinating antibody titer, and only 4 developed precipitating antibodies. None of the 10 patients who did not have visceral candidiasis on autopsy exhibited a rise in antibody titer before death. A correct antemortem diagnosis of visceral candidiasis was made in only four patients. A significant rise in antibody titer is a reliable indicator of visceral candidiasis and will increase the frequency with which an antemortem diagnosis of visceral candidiasis is made and thus will permit antifungal treatment to be administered. It is suggested that all patient groups that are at high risk with respect to fungal disease be followed with periodic determination of agglutinating antibody titer.
PREISLER HD, HASENCLEVER HF, LEVITAN AA, et al. Serologic Diagnosis of Disseminated Candidiasis in Patients with Acute Leukemia. Ann Intern Med. 1969;70:19–25. doi: 10.7326/0003-4819-70-1-19
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Published: Ann Intern Med. 1969;70(1):19-25.
Hematology/Oncology, Infectious Disease, Leukemia/Lymphoma.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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