ALAN S. COHEN, M.D.
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The earliest experimental models for the study of the pathogenesis of amyloidosis were animals inoculated with a variety of bacteria. The literature1 was reviewed in 1916 by Bailey (1) who remarked on the diversity of agents and the variability in the results. He then injected rabbits repeatedly with beef-extract broth cultures of colon bacillus and induced amyloid without suppuration in a number of animals. Subsequently, both gram-positive and gram-negative organisms as well as the tubercle bacillus have been associated with amyloid in experimental animals and in patients (2). Bacterial toxins (including diphtheria, streptococcus, and pneumococcus toxins) and dozens of substances
COHEN AS. Pathogenesis of Amyloidosis. Ann Intern Med. ;70:418–419. doi: 10.7326/0003-4819-70-2-418
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Published: Ann Intern Med. 1969;70(2):418-419.
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