KAREL HORKÝ, M.D.; OTO KÜCHEL, M.D.
This content is PDF only. Please click on the PDF icon to access.
Aminoglutethimide (Elipten® CIBA) is derived from the nonbarbiturate hypnotic glutethimide (Doriden®) from which it differs only by the presence of an —NH2 group. It has been used for several years as an anticonvulsant drug. However, its prolonged use leads to side effects, the most serious of which is hypoadrenocorticism. More detailed analysis of its action has shown that it blocks the formation of adrenal hormones in the very early steps of steroid biosynthesis—the conversion of cholesterol to Δ5-pregnenolon (1, 2). This block is achieved through competitive inhibition of the mitochondrial desmolase side-chain-splitting enzyme (3). In addition to this main effect
HORKÝ K, KÜCHEL O. Aminoglutethimide (Elipten® CIBA)—A New Inhibitor of Steroid Biosynthesis. Ann Intern Med. 1969;70:866–867. doi: 10.7326/0003-4819-70-4-866
Download citation file:
Published: Ann Intern Med. 1969;70(4):866-867.
Results provided by:
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use