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The discovery of insulin in 1921 changed profoundly the nosology of diabetes mellitus and the fate of the diabetic patient. Yet, after almost 50 years of arduous and unusually fruitful research, the pathogenesis of the disease is still shrouded in mystery and as controversial as ever. The factors that lead to absolute or relative insulin deficiency are still obscure. Although insulin has been crystallized, analyzed, and synthesized, the stages of its biological production, its release, and its degradation are still under investigation. Although we now recognize that insulin is an anabolic rather than only a carbohydrate regulating hormone with independent
Handbook of Diabetes Mellitus. Pathophysiology and Clinical Considerations.. Ann Intern Med. 1969;70:880–881. doi: https://doi.org/10.7326/0003-4819-70-4-880
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Published: Ann Intern Med. 1969;70(4):880-881.
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