Colin M. MacLeod, M.D.
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During World War II it was shown that immunization of troops in an army camp where pneumococcal pneumonia was epidemic by means of a polyvalent preparation of purified capsular polysaccharides prevented infection caused by types of pneumococcus present in the vaccine but did not affect the prevalence of the disease caused by other types. Although polyvalent polysaccharide prepararations were available commercially for several years thereafter, they did not come into general use chiefly because of the introduction of a variety of potent antibiotics during the same period. The meticulous studies of Austrian over the last 15 years on the high
MacLeod CM. The James D. Bruce Memorial Lecture: Prevention of Pneumococcal Pneumonia by Immunization with Purified Polysaccharides.. Ann Intern Med. ;70:1059. doi: 10.7326/0003-4819-70-5-1059_2
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Published: Ann Intern Med. 1969;70(5):1059.
Infectious Disease, Pneumonia, Pulmonary/Critical Care.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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