John H. Bland, M.D., F.A.C.P.; John W. Frymoyer, M.D.
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Connective tissue endocrinology is relatively unexplored, although rheumatic syndromes may characterize certain endocrine diseases. From 1954 to 1967, 74 undiagnosed rheumatic disease patients were clinically diagnosed as having hypothyroidism and myxedema in rheumatic disease clinics and private practices; laboratory confirmation followed in 38 patients; 5 patients had no objective supporting system signs; and 22 patients were excluded due to other accompanying causes for rheumatic symptoms and signs. Eleven myxedema patients are reported, all referred by internists for "arthritis." All recovered completely on thyroid replacement therapy.
The clinical, radiologic, and biochemical characteristics of rheumatic syndromes of hypothyroidism and myxedema are presented,
Bland JH, Frymoyer JW. Rheumatic Syndromes of Hypothyroidism and Myxedema.. Ann Intern Med. ;70:1060. doi: 10.7326/0003-4819-70-5-1060_1
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Published: Ann Intern Med. 1969;70(5):1060.
Endocrine and Metabolism, Rheumatology, Thyroid Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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