Jerome M. Hershman, M.D., F.A.C.P.; Dale G. Read, M.D.; Timothy B. Gibson, M.D.; Ann L. Bailey, B.S.
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The serum levels of several hormones of the anterior pituitary gland vary acutely in response to various stresses. We measured human thyrotrophin (TSH) in unextracted serum samples by a sensitive specific radioimmunoassay. The mean level in euthyroid adults was 4.43 ± 1.64 µunits/ml (mean ± SD). In 17 patients with primary hypothyroidism serum TSH was 24 to 160 µunits/ml, clearly differentiating this condition from secondary hypothyroidism in which TSH was not detected. Serum TSH was normal in patients with simple goiter, acromegaly, Cushing's disease, and choriocarcinoma.
In pregnant women late in the third trimester serum TSH averaged 4.56 µunits/ml. This
Hershman JM, Read DG, Gibson TB, et al. Utility of the Radioimmunoassay of Serum Thyrotropin.. Ann Intern Med. 1969;70:1062–1063. doi: 10.7326/0003-4819-70-5-1062_3
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Published: Ann Intern Med. 1969;70(5):1062-1063.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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