David E. Barnardo, M.R.C.P.; Cameron G. Strong, M.D.; William P. Baldus, M.D., F.A.C.P.
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Increased activity of the renin-angiotensin system in cirrhosis may aggravate salt and water retention by promoting the release of aldosterone. It has been postulated that elevation of plasma renin activity (PRA) due to increased production by the kidney may be augmented by impaired hepatic inactivation in the diseased liver, but this is unconfirmed.
Therefore, PRA was measured by the method of Boucher and associates in blood taken simultaneously from the hepatic vein and a peripheral vein or artery (there being no significant arterioventricular difference) in 18 patients with cirrhosis and 13 control subjects without liver disease.
As expected, peripheral PRA
Barnardo DE, Strong CG, Baldus WP. Elevated Hepatic Venous Renin Activity in Cirrhosis: Evidence for Impaired Hepatic Inactivation and Portal Venous Origin.. Ann Intern Med. ;70:1065. doi: 10.7326/0003-4819-70-5-1065_2
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Published: Ann Intern Med. 1969;70(5):1065.
Gastroenterology/Hepatology, Liver Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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