Eugene L. Coodley, M.D., F.A.C.P.
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Preliminary studies have suggested that serum guanase may be a sensitive index of liver cell damage, and the development of newer, simplified analytic procedures has stimulated this study of the new enzyme procedure in a series of patients with hepatobiliary diseases.
A series of 75 patients with either hepatitis or other causes of jaundice were studied with simultaneously performed serum guanase, serum glutamic-oxalacetic transaminase, serum glutamic-pyruvic transaminase, and serum bilirubin determinations.
Serum guanase was significantly elevated in 48 of 54 patients with hepatitis and in only 5 of 21 patients with various other causes of jaundice, including cirrhosis, extrahepatic obstruction,
Coodley EL. Serum Guanase in Differential Diagnosis of Jaundice.. Ann Intern Med. ;70:1066. doi: 10.7326/0003-4819-70-5-1066_1
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Published: Ann Intern Med. 1969;70(5):1066.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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