Lawrence D. Baker, M.D.; Juan C. Pomposiello, M.D.; Jerry A. Snow, M.D.; Joseph V. Messer, M.D.
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Alterations in myocardial oxygen and lactate extraction during exercise and isoproterenol infusion permit estimation of the metabolic consequences of coronary artery disease. The effects of these stresses are often poorly tolerated, elicit complex total-body metabolic changes, are difficult to quantitate reproducibly, and cannot be terminated abruptly. Pacemaker-induced tachycardia is well tolerated, easily controlled, reproducible, and has few extracardiac effects. The efficacy of pacemaker-induced tachycardia in eliciting metabolic abnormalities was assessed in six patients with cineangiographically proved anterolateral coronary artery disease by measuring regional myocardial oxygen and lactate extraction during rest and pacemaker-induced tachycardia and isoproterenol infusion (1 to 4 µg/min)
Baker LD, Pomposiello JC, Snow JA, et al. The Effects of Pacemaker-Induced Tachycardia on Myocardial Metabolism in Human Coronary Artery Disease (CAD).. Ann Intern Med. 1969;70:1073–1074. doi: 10.7326/0003-4819-70-5-1073_3
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Published: Ann Intern Med. 1969;70(5):1073-1074.
Cardiology, Rhythm Disorders and Devices.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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