Leonard W. Ritzmann, M.D.; Cameron C. Bangs, M.D.; Diane Coiner, B.S.; John M. Custis, B.S.; John R. Walsh, M.D.
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The use of serum glycoside concentrations in assessing digitalis toxicity was studied. Lowenstein's method for glycoside levels was adapted for clinical use by modifications giving greater accuracy and rapidity. This assay is based on the observation that small concentrations of glycoside inhibit the erythrocyte uptake of radioisotope rhubidium-86 (86Rb). Dichloromethane extract of glycoside from the patient's serum was incubated 2 hr with a red cell suspension and 86Rb. After five saline washings, the erythrocyte 86Rb radiation was measured in a well counter. The serum glycoside level was then determined by comparison of the 86Rb counts to standard curves obtained from
Ritzmann LW, Bangs CC, Coiner D, Custis JM, Walsh JR. Serum Glycoside Concentrations in Digitalis Toxic Patients.. Ann Intern Med. ;70:1080. doi: 10.7326/0003-4819-70-5-1080_2
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Published: Ann Intern Med. 1969;70(5):1080.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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