Ediz Z. Ezdinli, M.D.; Avery Sandberg, M.D.; Joseph E. Sokal, M.D., F.A.C.P.
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Chromosomal studies were performed in 76 cases of chronic myelocytic leukemia (initial diagnosis) using a direct technique for examination of bone marrow cells, except for a few cases in which resort to study of cultured peripheral blood cells was necessary. Of the 76 patients, 49 were Ph1-positive. These included 1 whose final clinical diagnosis was myeloblastic leukemia, 1 with erythroleukemia, and 3 with myeloid metaplasia; 44 patients (90%) were classified as having unequivocal chronic myelocytic leukemia. The 27 Ph1-negative patients included 4 whose final diagnosis was myeloblastic leukemia, 2 with eosinophilic leukemia, 1 with myeloid metaplasia, and 2 with leukemoid
Ezdinli EZ, Sandberg A, Sokal JE. Definition of Chronic Myelocytic Leukemia (CML) According to the Ph1 Chromosome.. Ann Intern Med. ;70:1083. doi: 10.7326/0003-4819-70-5-1083_1
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Published: Ann Intern Med. 1969;70(5):1083.
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