Edward P. Cohen, M.D.
This content is PDF only. Please click on the PDF icon to access.
Previously, we reported that a ribonucleic acid (RNA) extract from the spleens of immunized mice converted in vitro a small proportion of nonimmune spleen cells to form specific antibody (J. Immun. 95: 583, 1965). Miller and associates (J. Exp. Med. 128: 801, 1968) demonstrated that the cells responsible for antibody formation when thymectomized mice were reconstituted with intact thymocytes originated in the host and were not thymus-derived cells. Control mice not given thymocytes failed to produce antibody. This suggested that a substance was transferred from thymus-derived cells to host cells. To determine if such a mediator might be detected in
Cohen EP. Conversion of Nonimmune Cells to Antibody-Forming Cells with an RNA-Extract from the Thymus.. Ann Intern Med. ;70:1088. doi: 10.7326/0003-4819-70-5-1088_1
Download citation file:
Published: Ann Intern Med. 1969;70(5):1088.
Results provided by:
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use