Lyndall Molthan, M.D.
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Hemagglutinating antibodies (19S-f7S) have been found in the serum of 73 persons historically allergic to penicillins using test cells coated with cephalothin. Only 31 of these sera also reacted with test cells coated with penicillin G. It is believed that cephalothin produces a more sensitive test cell because of its marked affinity for protein-red cell membrane protein in this situation. It is also believed that hemagglutinating penicillin antibodies consider cephalothins and penicillins as the same antigen.
Twenty-six patients with hemagglutinating penicillin antibodies have received cephalothin therapeutically. Seventeen of these patients were allergic to penicillin by history; six had allergic reactions
Molthan L. Reactions to Cephalothins in Patients with Hemagglutinating Penicillin Antibodies.. Ann Intern Med. ;70:1090–1091. doi: 10.7326/0003-4819-70-5-1090_3
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Published: Ann Intern Med. 1969;70(5):1090-1091.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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