David R. Nalin, M.D.; Richard A. Cash, M.D.; Robert A. Phillips, M.D.
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This study was designed to develop an oral solution that could reduce the need for intravenous fluids for replacement of stool water and electrolyte losses in cholera.
Cholera patients in shock were given intravenous fluid until blood pressure was normal. Subsequent losses of stool and vomitus were replaced by an oral solution of electrolytes with either glucose or glycine as a substrate for sodium absorption. Fluid losses were subtracted from oral input, and the result was used as an index of oral hydration. Overall hydration was correlated with serial vital signs, weights, plasma electrolytes, and plasma specific gravities.
Nalin DR, Cash RA, Phillips RA. Oral Maintenance Therapy for Cholera in Adults.. Ann Intern Med. ;70:1091. doi: 10.7326/0003-4819-70-5-1091_1
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Published: Ann Intern Med. 1969;70(5):1091.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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