Gary L. Huber, M.D.; Theodore N. Finley, M.D.
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Increased oxygen tension as therapy for respiratory failure is frequently encountered clinically. A syndrome of progressive respiratory distress, pulmonary edema, and increased surface tension was induced in 10 mongrel dogs by exposure to oxygen tensions greater than 550 mm Hg for 52 hr. Pulmonary surfactant was recovered by endotracheal washing for lipid analysis and surface-activity determinations. Biopsies were taken for light and electron microscopy. Five dogs developing respiratory distress without pulmonary edema had normal surface tension values (0 to 11 dynes/cm). Three dogs developed pulmonary edema, with elevated pulmonary surface tension (13 to 25 dynes/cm). Light microscopy revealed perivascular and
Huber GL, Finley TN. Alterations in Pulmonary Morphology and Surface Activity During Experimental Oxygen Toxicity.. Ann Intern Med. ;70:1097. doi: 10.7326/0003-4819-70-5-1097_3
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Published: Ann Intern Med. 1969;70(5):1097.
Emergency Medicine, Pulmonary/Critical Care.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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