Selim Baruh, M.D.
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The site and rate of entry of insulin into the body may affect its metabolic actions. This study tested for the first time in man the hypothesis that the mode of action of endogenous insulin differs from peripherally injected insulin.
In 11 nondiabetic and 6 diabetic patients we compared the effects on peripheral glucose utilization of the following:  glucagon-free insulin rapidly injected and slowly infused into the portal circulation via percutaneous splenic puncture;  peripheral intravenous insulin; and  peripheral intravenous sodium tolbutamide. The arteriovenous glucose difference (AV) and AV/A ratios were calculated as values for measuring peripheral glucose
Baruh S. Peripheral Glucose Utilization in Man After Insulin Injection into Peripheral and Portal Circulation.. Ann Intern Med. ;70:1100. doi: 10.7326/0003-4819-70-5-1100_1
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Published: Ann Intern Med. 1969;70(5):1100.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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