A. Lopez-S., M.D., Ph.D.; S. R. Srinivasan, Ph.D.; B. Radhakrishnamurthy, Ph.D.; G. S. Berenson, M.D., F.A.C.P.
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The ability of serum low-density lipoproteins to form complexes with different polyanions has been previously described, but the mechanisms by which these complexes are formed remains obscure. The potential of lipoproteins to complex with acid mucopolysaccharides in vascular intima is important to the pathogenesis of atherosclerosis. The in vitro conditions for optimum formation of complexes have been studied. Chromatographic (column) and electrophoretic (paper, gel, and immunoelectrophoresis) evidence indicates the formation of complexes between beta lipoproteins with mucopolysaccharides. Calcium, phospholipids of beta lipoproteins, and certain reactive groups of mucopolysaccharides seem to be essential for complexing. Using different levels of calcium and
Lopez-S. A, Srinivasan SR, Radhakrishnamurthy B, et al. Complexing of Acid Mucopolysaccharides and Serum Beta-Lipoproteins.. Ann Intern Med. 1969;70:1102. doi: https://doi.org/10.7326/0003-4819-70-5-1102_1
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Published: Ann Intern Med. 1969;70(5):1102.
Cardiology, Coronary Risk Factors, Dyslipidemia.
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