Stanley R. Platman, M.D.; Leslie Baer, M.D.; Ronald R. Fieve, M.D.
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Evidence has accumulated for 70 years suggesting the relationship between electrolyte and fluid balance and the cyclic effective disorders. Recent studies in humans with affective disorders, utilizing isotope dilution techniques and body compartment measurements, have shown changes in sodium and body fluids which correlate with behavioral changes. This relationship is strengthened by the therapeutic efficiency of lithium in mania.
Body compartment measurements and fluid balance have been studied in the mood changes of manic-depressive disease. The effects of lithium have been evaluated in those patients with or without therapeutic response. The mechanisms for abnormalities in sodium retention and fluid redistribution
Platman SR, Baer L, Fieve RR. An Investigation of Electrolyte and Fluid Distribution in the Affective Disorders.. Ann Intern Med. 1969;70:1103. doi: https://doi.org/10.7326/0003-4819-70-5-1103_2
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Published: Ann Intern Med. 1969;70(5):1103.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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