Howard R. Bierman, M.D., F.A.C.P.; Melvin L. Winer, M.D.; Ervin T. Kovacs, M.D.; John A. Bruner, M.D.
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Iodine-131 and flourine-18 concentrate selectively in neoplastic osseous lesions. Nonradioactive fluorides (NaF, Na2PO8F, and KF) have been administered orally during the past 4 years to patients with neoplastic bone lesions arising from the breast, lung, kidney, pancreas, colon, and multiple myeloma in doses of 25 to 200 mg/day. Increased opacification in osteolytic and osteoblastic lesions was demonstrated by roentgenography within 4 to 6 months in 30 patients (40%) and was characterized by a dense, irregular, but diffuse sclerotic pattern.
Relief of bone pain preceded and often coincided with the sclerotic densification. Postmortem findings of increased hardness of these bones were
Bierman HR, Winer ML, Kovacs ET, et al. Fluoride-Calcium Deposition in Neoplastic Osteolytic Lesions.. Ann Intern Med. 1969;70:1105. doi: https://doi.org/10.7326/0003-4819-70-5-1105_2
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Published: Ann Intern Med. 1969;70(5):1105.
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