Melvin L. Reed, M.D.; V. K. Vaitkevicius, M.D., F.A.C.P.; Clarence B. Vaughn, M.D.
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Systemic 5-fluorouracil (5-FU) therapy of gastroitestinal tumors produces objective tumor remissions in 12 to 20% of patients. Drug toxicity prevents administration of sufficient amounts of 5-FU to induce higher regression rates. With tuomrs limited to the liver, systemic therapy can be avoided. The liver receives a double blood supply, approximately 90 to 95% from the portal vein and 5 to 10% from the hepatic artery. Primary or metastatic tumor in the liver receives approximately 5 to 10% from the portal vein and 90 to 95% from the hepatic artery. Infusion of cytotoxic drugs directly into the hepatic artery delivers all
Reed ML, Vaitkevicius VK, Vaughn CB. Chronic Hepatic Artery Infusion Therapy of Primary and Metastatic Hepatic Malignancies.. Ann Intern Med. 1969;70:1106. doi: 10.7326/0003-4819-70-5-1106_1
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Published: Ann Intern Med. 1969;70(5):1106.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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