Joseph E. Sokal, M.D., F.A.C.P.; C. William Aungst, M.D.
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Prognosis in Hodgkin's disease is notoriously difficult. Some patients die rapidly despite early and aggressive therapy, while others with various combinations of unfavorable prognostic signs live for very many years. This variability is attributed to differences in "host resistance." The intimate relationship of defects in cellular immune mechanisms with the course of Hodgkin's disease led us to the hypothesis that host resistance in this disease is directly related to the integrity of these mechanisms. If so, assessment of cellular immune capacity should have significant prognostic value. To test this, 32 tuberculin-negative patients with advanced Hodgkin's disease (stage III, 9; stage
Sokal JE, Aungst CW. An Immunologic Test for Prognosis in Advanced Hodgkin's Disease.. Ann Intern Med. 1969;70:1106–1107. doi: 10.7326/0003-4819-70-5-1106_3
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Published: Ann Intern Med. 1969;70(5):1106-1107.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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