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Every disease, it may be assumed, begins as a molecular disorder. As such perturbations multiply defects in cellular function develop to be followed by tissue deficiencies, possibly by organ shortcomings, and finally by systemic manifestations. Somewhere along this pathogenetic rosary, symptoms or signs appear and a disease is recognized, a well man becomes a patient, and a physician may or may not be consulted. The physician will cope with his patient's problem on the basis of his understanding of the mechanisms involved in the production of the disease. His knowledge may be scant or considerable and will lie somewhere along
Pathology of the Heart and Blood Vessels.. Ann Intern Med. 1969;70:1289–1290. doi: https://doi.org/10.7326/0003-4819-70-6-1289
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Published: Ann Intern Med. 1969;70(6):1289-1290.
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