PIERCE GARDNER, M.D.; DAVID H. SMITH, M.D.
In a nosocomial outbreak due to multidrug-resistant Klebsiella, resistance (R) factors were found to mediate drug resistance in 90% of the isolates tested. An analysis of Klebsiella isolates and a prospective study of interbacterial transfer of R factors in hospital patients both suggested that environmental selection by antibiotics and colonization of patients with resistant organisms are of far greater epidemiological significance than transfer of R factors in the gastrointestinal tract. The public health implications are discussed.
GARDNER P, SMITH DH. Studies on the Epidemiology of Resistance (R) Factors: I. Analysis of Klebsiella Isolates in a General Hospital: II. A Prospective Study of R Factor Transfer in the Host. Ann Intern Med. ;71:1–9. doi: 10.7326/0003-4819-71-1-1
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Published: Ann Intern Med. 1969;71(1):1-9.
Hospital Medicine, Infectious Disease.
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