PAUL STEER, M.D.; RICHARD MARNELL, M.D.; EMILE E. WERK JR., M.D.
A 43-year-old man is described who fulfills the usual criteria for both alcohol hypoglycemia and isolated adrenocorticotrophic hormone (ACTH) deficiency. This is the fifth such patient reported. However, this patient was unique in that the ACTH deficiency seemed limited to the cortisol feedback whereas the response to hypoglycemia was normal. The question arises whether there was truly an aberration in the cortisol servomechanism or whether the diagnostic criterion (metyrapone test) is unsatisfactory. In any event maintenance glucocorticoid therapy resulted in remarkable clinical benefit.
STEER P, MARNELL R, WERK EE. Clinical Alcohol Hypoglycemia and Isolated Adrenocorticotrophic Hormone Deficiency. Ann Intern Med. 1969;71:343–348. doi: https://doi.org/10.7326/0003-4819-71-2-343
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Published: Ann Intern Med. 1969;71(2):343-348.
Adrenal Disorders, Endocrine and Metabolism, Neurology, Pituitary Disorders.
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