JULIUS A. KASEL, PH.D.; ROGER D. ROSSEN, M.D.; ROBERT V. FULK, M.D.; DAVID S. FEDSON, M.D.; ROBERT B. COUCH, M.D.; PAUL BROWN, M.D.
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The studies presented in this Conference illustrate some of the newer aspects of the immune response to infection with influenza virus and vaccination with inactivated vaccines. The predominant immunoglobulin in respiratory secretions is an 11S IgA dimer that is distinguishable from serum IgA. Intranasal immunization with inactivated vaccines resulted in higher titers and greater duration of antibody in respiratory secretions than did subcutaneous vaccination. In addition, if given in adequate dosages, vaccination by this method resulted in significant levels of humoral antibody in most vaccinees. The degree of both serum and nasal antibody responses was shown to be related to the age and prior immunologic experience of the vaccinated individual. Initial studies from challenge experiments suggested that intranasal vaccination was as effective as subcutaneous vaccination in reducing infection.
KASEL JA, ROSSEN RD, FULK RV, FEDSON DS, COUCH RB, BROWN P. Human Influenza: Aspects of the Immune Response to Vaccination. Ann Intern Med. ;71:369–398. doi: 10.7326/0003-4819-71-2-369
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Published: Ann Intern Med. 1969;71(2):369-398.
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