IRA D. GOLDFINE, M.D.; HOWARD SCHACHTER, M.D.; WILLIAM R. BARCLAY, M.D.; HENRY S. KINGDON, M.D., PH.D.
A 56-year-old woman required hospitalization and endotracheal intubation because of progressive respiratory distress associated with bilateral diffuse pulmonary infiltrates. Within 12 hr she developed massive bleeding from a rectal hemorrhoid. Coagulation studies were consistent with a consumption coagulopathy. Despite heparin therapy the patient died. Postmortem examination showed that the immediate cause of death was an intracerebral hemorrhage. In addition there was extensive miliary tuberculosis with early granuloma formation. Histologic sections of the lung and kidney showed fibrin thrombi surrounding areas of caseation necrosis. Extensive fibrin thrombus formation in association with massive numbers of evolving tubercles is postulated as the cause of the consumption coagulopathy in this patient.
GOLDFINE ID, SCHACHTER H, BARCLAY WR, et al. Consumption Coagulopathy in Miliary Tuberculosis. Ann Intern Med. 1969;71:775–777. doi: 10.7326/0003-4819-71-4-775
Download citation file:
Published: Ann Intern Med. 1969;71(4):775-777.
Coagulopathies, Hematology/Oncology, Infectious Disease, Mycobacterial Infections.
Results provided by:
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use