YUKIO OCHI, M.D.; LESLIE J. DEGROOT, M.D.
Six instances of vitiligo involving chiefly the hands and feet occurred among 90 patients with Graves' disease. The vitiligo usually preceded the onset of the symptoms of Graves' disease. Autoantibodies against thyroid were present in five of six patients, and long-acting thyroid stimulator (LATS) was present in three of six. The vitiligo may be another manifestation of autoimmunity. When present it is a helpful clinical diagnostic point suggesting the presence of Graves' disease.
OCHI Y, DEGROOT LJ. Vitiligo in Graves' Disease. Ann Intern Med. ;71:935–940. doi: 10.7326/0003-4819-71-5-935
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Published: Ann Intern Med. 1969;71(5):935-940.
Endocrine and Metabolism, Thyroid Disorders.
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