G. E. BURCH, M.D., F.A.C.P.; H. L. COLCOLOUGH, M.D.
A patient had clinical features of progressive pancarditis and nephritis. The illness and subsequent death followed a course initiated by a viral infection with Coxsackie virus B4. Detailed gross, histologic, electron microscopic, and immunofluorescent studies indicated the Coxsackie virus B4 antigen was found within areas of maximal damage in the aortic valve, myocardium, pericardium, and kidneys. A reactivated or progressive viral infection probably caused the death of this patient. The role of Coxsackie B viruses and that of other viruses in the production of heart and real disease are discussed. Further clinicopathologic investigations are needed in this area.
BURCH GE, COLCOLOUGH HL. Progressive Coxsackie Viral Pancarditis and Nephritis. Ann Intern Med. 1969;71:963–970. doi: 10.7326/0003-4819-71-5-963
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Published: Ann Intern Med. 1969;71(5):963-970.
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