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Among the diagnostic problems that confront clinicians, some of the most frustrating are those involving associations between drug administration and the subsequent appearance of undesirable signs and symptoms or abnormal laboratory data. Do these changes represent unexpected facets of the disease being treated or has another, unrelated disease appeared? Should the suspected drug be discontinued? Would a "rechallenge" at a later date be safe and of value? The clinician seeking answers to such questions finds the general clinical literature replete with imprecise and confusing "data" derived largely from "testimonial" case reports.
Meyler and his associates have carefully and systematically searched
Side Effects of Drugs. A Survey of Unwanted Effects of Drugs.. Ann Intern Med. ;71:1037. doi: 10.7326/0003-4819-71-5-1037_2
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Published: Ann Intern Med. 1969;71(5):1037.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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