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Interferon is a natural antiviral cellular protein stimulated by viruses, various microorganisms, and complex compounds such as endotoxin and nucleic acids. It is really a class of proteins (like globulins) and should be called interferons. Since its discovery in 1959 by Isaacs and Lindenmann, it has become increasingly popular in research and in explaining antiviral mechanisms. Its initial promise as an antiviral therapeutic agent is still unfulfilled. As yet there is no preparation of interferon that is sufficiently potent or pure for use in man. Nor is there an adequate inducer or stimulator of interferon that is nontoxic enough to
Interferon.. Ann Intern Med. 1969;71:1224–1225. doi: https://doi.org/10.7326/0003-4819-71-6-1224_2
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Published: Ann Intern Med. 1969;71(6):1224-1225.
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