C. E. BUCKLEY III, M.D.; F. C. DORSEY, M.A.
Changes in the three major immunoglobulins in patients with sarcoidosis and tuberculosis were studied with respect to age, race, and sex. IgG and IgM were increased in patients with sarcoidosis, IgG in patients with tuberculosis. Differences between serum immunoglobulin concentrations in patients with sarcoidosis and tuberculosis were not significant. The restriction of significant hyperglobulinemia to specific race and sex combinations was of special interest. In patients with sarcoidosis the increase in IgG was significant in white patients, and the increase in IgM was significant only in black patients. A similar race-associated pattern could be demonstrated in patients with tuberculosis. Evaluation of hyperglobulinemia with respect to sex showed that the increase in IgM in sarcoidosis was only significant in black women. White men with tuberculosis showed increased IgG and IgA. Changes observed in specific race and sex combinations may provide a basis for interrelating these differences with variations in the natural history of each disease.
BUCKLEY CE, DORSEY FC. A Comparison of Serum Immunoglobulin Concentrations in Sarcoidosis and Tuberculosis. Ann Intern Med. 1970;72:37–42. doi: https://doi.org/10.7326/0003-4819-72-1-37
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Published: Ann Intern Med. 1970;72(1):37-42.
DOI: 10.7326/0003-4819-72-1-37
Infectious Disease, Mycobacterial Infections.
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