ROGER J. BULGER, M.D.; ELAINE LARSON, R.N.; JOHN C. SHERRIS, M.D.
Antibiograms were reviewed of all strains of Escherichia coli and Klebsiella-Enterobacter isolated from lesions of patients at the University of Washington Hospital, Seattle, from mid-1959 through 1968. No trend to increasing resistance to any of the chemotherapeutics tested was noted among the isolates of E. coli or Klebsiella-Enterobacter, and declining resistance was evident. E. coli showed an increase of strains resistant to none or only one of the seven agents and a decrease in multiply resistant strains. The frequency of E. coli bacteremia has not increased since 1959-1960 and 1961, and the antibiograms of organisms isolated from the blood generally coincided with the antibiograms of the total population. The incidences of Klebsiella-Enterobacter strains resistant to the seven chemotherapeutic agents also diminished as did that of multiply resistant strains. In contrast to E. coli, the frequency of klebsiella-enterobacter bacteremia did not diminish during the first 7 years; during the subsequent 3 years there was a marked decrease in frequency of positive blood cultures. The incidences of resistance to tetracycline and streptomycin may be associated with the amounts used per patient.
BULGER RJ, LARSON E, SHERRIS JC. Decreased Incidences of Resistance to Antimicrobial Agents Among Escherichia coli and Klebsiella-Enterobacter: Observations in a University Hospital over a 10-Year Period. Ann Intern Med. 1970;72:65–71. doi: 10.7326/0003-4819-72-1-65
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Published: Ann Intern Med. 1970;72(1):65-71.
Hospital Medicine, Infectious Disease.
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