ALEX B. LATTY, M.D.
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To the editor: In the September 1969 ANNALS Welch and associates make a significant contribution to the antitrypsin literature with the finding of no significant difference in the frequency of "heterozygote" antitrypsin deficiency among healthy persons versus patients with lung disease. However, they then deduce that this observation coupled with the very different clinical lung disease found among heterozygous and homozygous antitrypsin-deficient patients mitigates a significant role for antitrypsin deficiency in pulmonary disease. This conclusion is not warranted by their data. The differences in clinical presentations of their heterozygotes and homozygotes could well reflect a quantitative difference in the severity
LATTY AB. Antitrypsin Deficiency in Pulmonary Disease. Ann Intern Med. ;72:147–148. doi: 10.7326/0003-4819-72-1-147_2
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Published: Ann Intern Med. 1970;72(1):147-148.
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