E. Z. EZDINLI, M.D.; J. E. SOKAL, M.D., F.A.C.P.; L. CROSSWHITE, B.S.; A. A. SANDBERG, M.D.
Chromosomal studies were performed on 61 adult patients with "typical chronic myelocytic leukemia. The Philadelphia (Ph1) chromosome was found in 43 patients, with equal sex distribution and with a median age of 48 years. The 18 Ph1-negative (Ph1-) patients had a median age of 66 years and were predominantly male. Absent leukocyte alkaline phosphatase was noted with equal frequency in both groups. The Ph1- patients had lower white blood cell and platelet counts and did not respond as well to antileukemic therapy. Basophilia and abnormally high platelet counts were fairly common among Ph1-positive (Ph1+) patients. The incidence of blastic crisis was approximately 50% in both groups but appeared earlier in the Ph1-negative patients. Median survival of Ph1+ patients was 40 months; that of the Ph1- group, only 8. Karyotypic analysis furnishes a subclassification of myelocytic leukemia with significant prognostic and therapeutic implications.
EZDINLI EZ, SOKAL JE, CROSSWHITE L, et al. Philadelphia-Chromosome-Positive and -Negative Chronic Myelocytic Leukemia. Ann Intern Med. 1970;72:175–182. doi: 10.7326/0003-4819-72-2-175
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Published: Ann Intern Med. 1970;72(2):175-182.
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