H. ALLAN BLOOMER, M.D., F.A.C.P.; ROBERT K. MADDOCK JR., M.D.; JAMES B. SHEEHE, B.S.; ELTON J. ADAMS, B.A.
The increasing use of diuresis and dialysis for treating patients with drug coma has created a need for rapid and detailed toxicologic information about the unconscious patient. A gas chromatography method was used to screen plasma in 41 patients with suspected drug coma. In 37 instances either a barbiturate, meprobamate, glutethimide, or a combination of these sedatives was found in sufficient concentrations to explain the coma. In over one half of these cases the history available at the time of admission was unreliable for determining the responsible drug. Gas-liquid chromatography is uniquely suited for the rapid diagnosis of drug intoxication since it permits simultaneous identification and measurement of a variety of sedative agents.
BLOOMER HA, MADDOCK RK, SHEEHE JB, et al. Rapid Diagnosis of Sedative Intoxication by Gas Chromatography. Ann Intern Med. 1970;72:223–228. doi: https://doi.org/10.7326/0003-4819-72-2-223
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Published: Ann Intern Med. 1970;72(2):223-228.
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