O. S. BETTER, M.D.
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To the editor: AS pointed out in a paper in a recent issue of the ANNALS, acidosis may be a valuable early clue to rejection of the renal transplant (1). Observations in our laboratory support this finding (2). The suggestion that acidosis may be an indication for the intensification of immunosuppressive treatment (1) should, however, be accepted with great caution. There are probably other causes for tubular acidosis after transplantation than rejection. Acute tubular necrosis may be an important etiologic factor in the genesis of the defects in urinary acidification (3, 4) at least in the early post-transplant period. Moreover,
BETTER OS. Acidosis in Renal Allograft Rejection. Ann Intern Med. ;72:288. doi: 10.7326/0003-4819-72-2-288_2
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Published: Ann Intern Med. 1970;72(2):288.
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