DOROTHY T. KRIEGER, M.D.; DAVID K. SIROTA, M.D.; THEODORE LIEBERMAN, M.D.
Transphenoidal cryohypophysectomy was performed on 20 diabetic subjects with retinopathy. Preoperative fundoscopic findings were hemorrhagic activity and neovascularization with proliferation. Completeness of hypophysectomy was evaluated by tests involving determination of growth-hormone responsiveness to infusion of 2-deoxy-D-glucose and thyroid, adrenal and gonadotrophic function. All tests were performed pre- and postoperatively.
Sixteen patients were followed for an average of 38.4 months. Improved vision was noted in 19%, stabilization in 25%, and progression in 56%. This percentage is concordant with that noted in studies of the natural history of diabetic retinopathy. There was no correlation between the degree of improvement in the retinopathy and the presence or absence of complete hypophysectomy.
KRIEGER DT, SIROTA DK, LIEBERMAN T. Cryohypophysectomy for Diabetic Retinopathy: Ophthalmological and Endocrine Correlation. Ann Intern Med. ;72:309–316. doi: 10.7326/0003-4819-72-3-309
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Published: Ann Intern Med. 1970;72(3):309-316.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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