Theodore E. Woodward, M.D., F.A.C.P.
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Available inactivated vaccines for the salmonelloses and other bacterial diseases are limited in degree and duration of effectiveness and in their ability to prevent the toxic effects (antitoxic immunity) of the microbe. The cholera vibrio attaches to the ciliated intestinal epithelium, and its toxin causes excessive influx of body fluids into the intestinal lumen. A toxoided preparation of the exotoxin prevents diarrhea in animals. Biologic considerations in typhoid fever differ.
Once typhoid bacilli pass the intestinal barrier, active disease occurs regardless of the presence of flagellar, somatic, or Vi antibodies. Although repeated and large doses of Salmonella typhosa endotoxin produces
Woodward TE. The James D. Bruce Memorial Lecture: The Riddle of Typhoid Immunization.. Ann Intern Med. 1970;72:776. doi: https://doi.org/10.7326/0003-4819-72-5-776_1
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Published: Ann Intern Med. 1970;72(5):776.
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