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Goiter has been known to be endemic all along the Himalayas, involving India, Pakistan, Nepal, and Afghanistan. It extends into Burma and Thailand and is known to occur in Ceylon and Indonesia. Recent studies of Himalayan endemic goiter indicated that the endemic is attributable to environmental iodine deficiency. Iodine deficiency in the Himalayas is severe and is frequently accompanied by manifestations of developmental disturbances in the form of deaf-mutism and cretinism. The thyroid is enlarged and hyperplastic even at birth in this area, and nodular transformation occurs at a relatively young age. There is no evidence to suggest that inherited
Ramalingaswami V. ACP Honorary Fellowship Lecture: Endemic Goiter in Southeast Asia—New Clothes on Old Body.. Ann Intern Med. 1970;72:776. doi: 10.7326/0003-4819-72-5-776_3
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Published: Ann Intern Med. 1970;72(5):776.
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