Lawrence M. Higgs, M.D.; D. Luke Glancy, M.D., F.A.C.P.; Kevin P. O'Brien, M.R.C.P.; Stephen E. Epstein, M.D.
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The abnormal left ventricular hemodynamics frequently observed during angina have been interpreted as manifestations of transient cardiac failure. This study was done in 11 patients with arteriographically proved coronary disease, but no clinical evidence of failure, to determine if left ventricular hemodynamics during angina induced by graded (10-beat increments/min) atrial pacing could be altered by ouabain and to evaluate the effects of ouabain on the pacing rate necessary to provoke angina. Both before and 30 min after ouabain (0.01 mg/kg) measurements were made at rest, during pacing to angina, and on stopping pacing. Resting left ventricular end-diastolic pressure (LVEDP) averaged
Higgs LM, Luke Glancy D, O'Brien KP, et al. Effect of Digitalis on Left Ventricular Response to Atrial Pacing in Patients with Angina.. Ann Intern Med. 1970;72:778–779. doi: 10.7326/0003-4819-72-5-778_4
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Published: Ann Intern Med. 1970;72(5):778-779.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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