R. H. Unger, M.D., F.A.C.P.; E. Aguilar-Parada, M.D.; W. A. Muller, M.D.; A. M. Eisentraut
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Development of a specific radioimmunoassay for pancreatic glucagon made possible the study of alpha cell function in normal and diabetic subjects. In 28 normals fasting plasma glucagon averaged 108 μμg/ml (SEM±10); during hyperglycemia averaging 210 mg (±15) induced by intravenous glucose, glucagon fell to 62 μμg/ml/100ml (±8). Yet in 33 fasting adult- and 12 juvenile-type diabetics with fasting hyperglycemia of 177 (±10) and 198 mg/100 ml (±25), respectively, glucagon averaged 114 (±8) and 118 (±9) μμg/ml, suggesting hyposuppressibility of the diabetic alpha cell to glucose. The most striking hyposuppressibility was observed in eight patients with severe diabetic ketoacidosis, in whom
Unger RH, Aguilar-Parada E, Muller WA, et al. Abnormal Glucagon Secretion in Diabetes Mellitus.. Ann Intern Med. 1970;72:786. doi: 10.7326/0003-4819-72-5-786_3
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Published: Ann Intern Med. 1970;72(5):786.
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