Richard S. Lillehei, M.D.; Richard L. Simmons, M.D.; John S. Najarian, M.D.; F. C. Goetz, M.D.
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We have developed a technique of heterotopic pancreaticoduodenal allotransplantation in the dog. Drainage of exocrine secretions of the pancreaticoduodenal graft is into the jejunum of the host, and venous return of the graft is disected into the systemic venous system of the host. Pancreatectomized dogs with such allografts have survived many months if immunosuppressive drugs are given to prevent rejection. With this background we have made pancreaticoduodenal allografts combined with renal allografts in six patients with insulin-dependent, juvenile onset diabetes mellitus with terminal nephropathy. The recipients own pancreas has been left in place. Two such patients have now left the
Lillehei RS, Simmons RL, Najarian JS, et al. Pancreaticoduodenal and Renal Allotransplantation for Juvenile Diabetic Nephropathy.. Ann Intern Med. 1970;72:786–787. doi: https://doi.org/10.7326/0003-4819-72-5-786_4
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Published: Ann Intern Med. 1970;72(5):786-787.
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