Myron Miller, M.D., F.A.C.P.; Arnold M. Moses, M.D., F.A.C.P.
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Chlorpropamide has been shown to produce an antidiuresis when administered to patients with antidiuretic hormone (ADH)-sensitive diabetes insipidus (DI). The mechanism by which the drug acts has been studied both in patients with DI and in rats with hereditary hypothalamic DI and with a complete deficiency of ADH. Fourteen patients with various degrees of severity of DI and nine normal water loaded subjects were studied under metabolic conditions on a fixed sodium and potassium intake. By means of a dehydration test, 11 of the patients were shown to have some degree of residual ADH function while 3 patients were considered
Miller M, Moses AM. Mechanism of Chlorpropamide Action in Diabetes Insipidus.. Ann Intern Med. 1970;72:789–790. doi: 10.7326/0003-4819-72-5-789_4
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Published: Ann Intern Med. 1970;72(5):789-790.
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