Allan D. Thomson, M.D.; Herman Baker, Ph.D.; Carroll M. Leevy, M.D., F.A.C.P.
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Malabsorption of commercially available thiamine preparations is often responsible for clinical and laboratory evidence of a deficiency of this vitamin. Studies of thiamine propyl disulfide indicate its intestinal transport, unlike thiamine hydrochloride which is widely used as a food supplement, is not rate-limited. Absorption of these congeners was compared in 10 healthy volunteers and 10 malnourished alcoholics with normal blood (25 to 70 ng/ml) and spinal fluid (25 to 40 ng/ml) thiamine levels (Ochromonas danica). Therapeutic effectiveness of thiamine hydrochloride and thiamine propyldisulfide was investigated in eight alcoholics with Wernicke's encephalopathy and oculomotor palsy who had an average blood and
Thomson AD, Baker H, Leevy CM. Correction of Thiamine Depletion Syndromes Refractory to Oral Thiamine Hydrochloride.. Ann Intern Med. 1970;72:792. doi: 10.7326/0003-4819-72-5-792_1
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Published: Ann Intern Med. 1970;72(5):792.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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