Sheldon P. Rothenberg, M.D., F.A.C.P.; Rajani Kantha, M.D.
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Although the identification of antibodies (AB) against intrinsic factor in serum of some pernicious anemia (PA) patients has raised questions about pathogenesis of this disease, of more practical clinical value has been the use of such AB as an aid to rapid etiologic diagnosis of megaloblastic anemias. Two types of AB have been defined; one blocks intrinsic factor from binding B12, and a second binds intrinsic factor or intrinsic factor-B12. Identification of AB in serum supports with 99% certainty diagnosis of PA. A newly developed radioassay for AB using low substrate concentrations is more sensitive, rapid, and easily adapted to
Rothenberg SP, Kantha R. Clinical Use of Antibodies to Intrinsic Factor.. Ann Intern Med. 1970;72:795–796. doi: https://doi.org/10.7326/0003-4819-72-5-795_4
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Published: Ann Intern Med. 1970;72(5):795-796.
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