John F. Aloia, M.D.; Marion T. DiFiglia, M.D.; Richard A. Field, M.D., F.A.C.P.
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Current therapy for diabetes insipidus is far from ideal. The development of antivasopressin antibodies, hypersensitivity reactions, inconvenience of repeated injections of pitressin tannate, and short duration of action of vasopressin sprays and snuff led us to evaluate the drug chlorpropamide in the treatment of diabetes insipidus. Four patients with proved non-renal diabetes insipidus were admitted to the Clinical Research Center and studied under conditions of controlled intake and known output. Daily weight, urine volume, osmolal clearance (Cosm), creatinine clearance (Ccr), urinary sodium (VUNa), urinary potassium (VUK), and free-water clearance (CH20) were measured. Three patients also had inulin clearance (Cin) and
Aloia JF, DiFiglia MT, Field RA. Effect of Chlorpropamide on Free-Water Clearance, Diurnal Cycles of Renal Function, and Sodium Excretion in Diabetes Insipidus.. Ann Intern Med. ;72:801. doi: 10.7326/0003-4819-72-5-801_2
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Published: Ann Intern Med. 1970;72(5):801.
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