Kurt Lange, M.D., F.A.C.P.; Martin Semar; Inge Sagel, M.D.; Antonia Ty, M.D.; Gerhard Tresser, M.D.
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Parts of the glomerular basement membranes and the mesangium of kidney biopsies from patients with early acute poststreptococcal glomerulonephritis stain with the patient's own fluorescein-labeled gamma globulin (IgC). This staining occurs only on biopsies obtained during the first week of the disease, and the same sera do not stain kidney biopsies obtained from patients with any other renal disease or normal kidney tissue. Such sera stain the biopsies of kidney biopsies of other patients with poststreptococcal glomerulonephritis interchangeably. Preabsorption of such staining sera with disrupted group A streptococci from patients with this disease abolishes the staining capacity. Other disrupted bacteria
Lange K, Semar M, Sagel I, et al. The Significance of Streptococcal Components as Antigens in Acute Poststreptococcal Glomerulonephritis.. Ann Intern Med. 1970;72:801–802. doi: https://doi.org/10.7326/0003-4819-72-5-801_4
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Published: Ann Intern Med. 1970;72(5):801-802.
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