Gaddo Onesti, M.D.; Kwan Eun Kim, M.D., (Associate); Albert N. Brest, M.D., F.A.C.P.; Charles Swartz, M.D., F.A.C.P.
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Six uremic patients with malignant phase of essential hypertension were studied before and after bilateral nephrectomy. All patients had documented essential hypertension for 2 to 10 years. Histologic examination of all kidneys demonstrated malignant nephrosclerosis but no primary renal parenchymal disease or renal artery stenosis. The following values were measured twice a week before and after nephrectomy for 6 to 16 months: intra-arterial pressure, cardiac output, total peripheral resistance, blood volume, total exchangeable sodium, peripheral plasma renin. Diastolic blood pressure averaged 158 mm Hg before nephrectomy and 93 mm Hg after nephrectomy. The decrease in blood pressure after nephrectomy was
Onesti G, Kim KE, Brest AN, et al. Evidence for the Renal Origin of the Malignant Phase of Essential Hypertension.. Ann Intern Med. 1970;72:802. doi: https://doi.org/10.7326/0003-4819-72-5-802_4
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Published: Ann Intern Med. 1970;72(5):802.
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